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CLINICAL TRIALS AND EVIDENCE-BASED MEDICINES
University Health Industries uses the principles of evidence-based medicine (EBM) in designing all of its patent-pending formulations.
Evidence-based medicine is a new paradigm that is replacing the traditional, authority-based medical paradigm. In a nutshell, it is the “conscientious, explicit and judicious use of current best evidence in making decisions about individual patients. The practice of evidence-based medicine means integrating individual clinical expertise with the best available external clinical evidence from systematic research.”1

EBM involves evaluating a variety of evidence such as randomized controlled trials, systematic reviews of series of trials, meta-analyses, and other information collection and research methods. It also emphasizes the dissemination of information so that the evidence can reach clinical practice. It is closely linked with the Cochrane Collaboration, an international network of centers whose aim is to promote and foster the EBM approach by making accurate, up-to-date scientific evidence readily available to practitioners worldwide.
 
 
The chart below represents a hierarchal ordering of level (quality) of evidence from the best (1a) to the lowest (5). Evidence-based medicine is the paradigm that physicians now use to provide the best possible treatment to their patients. It is also the model that University Health Industries uses in designing its nutraceutical products.

Level

EVALUATION METHOD of the Therapy or Preventive

1a

Systematic review (meta-analysis)

1b

Individual randomized controlled trial

2a

Systematic review of cohort studies

2b

Individual cohort study

2c

Outcomes research

3a

Systematic review of case-control studies

3b

Individual case-control study

4

Case series

5

Expert opinion without explicit critical appraisal

 
1 David Sackett, et al. "Evidence Based Medicine: What It Is and What It Isn't," BMJ 312, no. 7023 (1996).
 
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